Description

11-Hydroxyrotenone is a naturally occurring isoflavonoid derivative and a key metabolite of the botanical insecticide rotenone. This compound is significant for its role in biochemical research, particularly in the study of mitochondrial complex I inhibition and its associated metabolic pathways. It is primarily utilized by researchers and manufacturers in the agrochemical, pharmaceutical, and life science sectors for analytical reference standards, metabolic studies, and as a precursor in specialized synthesis.

Application

• Analytical Reference Standard: Used as a high-purity standard in HPLC, LC-MS, and GC-MS for the quantification and identification of rotenone and its metabolites in environmental, agricultural, and biological samples.
• Biochemical Research: Serves as a critical tool in studying mitochondrial dysfunction, neurotoxicity, and the mechanisms of action of complex I inhibitors in cellular and animal models.
• Agrochemical Metabolite Studies: Employed in environmental fate and metabolism studies to understand the degradation pathways and ecological impact of rotenone-based pesticides.
• Pharmaceutical Intermediate: Acts as a building block or precursor in the research and development of novel therapeutic agents targeting specific enzymatic pathways.
• Toxicology and Safety Assessment: Utilized in laboratories to establish toxicological profiles and investigate the metabolic activation of related compounds.

Basic Information

Product Name	11-Hydroxyrotenone
CAS No.	82-10-0
Molecular Formula	C23H22O7
Molecular Weight	410.42 g/mol
Synonyms	11-Hydroxyrotenone; 6aβ,12aβ-11-Hydroxyrotenone; 11-Hydroxy-6aβ,12aβ-rotenone; Rotenone, 11-hydroxy-; 11-Hydroxyrotenon; NSC 163047; 11-Hydroxy-rotenone; 11-Hydroxyrotenon
EINECS	Contact for details

Quality Control

Our 11-Hydroxyrotenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic methods (NMR, MS) for structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and relevant physical data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider sealing under an inert gas such as argon or nitrogen.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.