Description

1,3-Dioxolane-4-Methanamine,α-(1,1-Difluoro-2-Propenyl)-2,2-Dimethyl-,(Alphas,4S)-(9Ci) is a high-value, stereochemically defined chiral building block used in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific fluorinated and heterocyclic motifs with high enantiomeric purity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluorinated propenyl group can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Potential building block for specialty polymers and advanced materials requiring specific fluorinated components.
• Process Chemistry: Employed in route scouting and scale-up for the commercial production of fine chemicals.
• Academic & Institutional Research: A valuable reagent for methodological studies in organic and medicinal chemistry.

Basic Information

Product Name	1,3-Dioxolane-4-Methanamine,α-(1,1-Difluoro-2-Propenyl)-2,2-Dimethyl-,(Alphas,4S)-(9Ci)
CAS No.	799257-15-1
Molecular Formula	C9H15F2NO2
Molecular Weight	207.22 g/mol
Synonyms	(4S)-α-(1,1-Difluoroallyl)-2,2-dimethyl-1,3-dioxolane-4-methanamine; (αS,4S)-α-(1,1-Difluoro-2-propen-1-yl)-2,2-dimethyl-1,3-dioxolane-4-methanamine; 1,3-Dioxolane-4-methanamine, α-(1,1-difluoro-2-propenyl)-2,2-dimethyl-, (αS,4S)-; (S,S)-Enantiomer of the difluoroallyl dioxolane amine; Chiral fluorinated dioxolane amine; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for sensitive synthetic applications. Quality is verified through comprehensive analytical techniques including Chiral HPLC, NMR, and GC/MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, enantiomeric excess, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.