Description

(1’S,2R)-2-[(1’,2’-o-Isopropylidene)Dihydroxyethyl]-6-Fluorochroman-4-One is a high-purity chiral fluorinated chromanone derivative, serving as a critical synthetic intermediate in advanced pharmaceutical research and development. Its precise stereochemistry and functional groups make it a valuable building block for constructing complex molecules with targeted biological activity. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Asymmetric Synthesis: Employed as a sophisticated building block for constructing complex, stereochemically defined molecular architectures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its fluorinated chromanone scaffold.
• Process Chemistry Development: Serves as a reference standard or starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Fine Chemical Production: Intermediate for the manufacture of specialty chemicals requiring high enantiomeric purity.
• Academic Research: Utilized in university and institutional labs for methodological development in organic and fluoroorganic chemistry.

Basic Information

Product Name	(1’S,2R)-2-[(1’,2’-o-Isopropylidene)Dihydroxyethyl]-6-Fluorochroman-4-One
CAS No.	797054-21-8
Molecular Formula	C₁₇H₂₁FO₅
Molecular Weight	324.35 g/mol
Synonyms	6-Fluoro-2-[(1S,2R)-1,2-dihydroxy-3,3-dimethylbutyl]chroman-4-one; (1S,2R)-2-(1,2-Dihydroxy-3,3-dimethylbutyl)-6-fluorochroman-4-one; 6-Fluoro-2-[(1S,2R)-1,2-dihydroxy-3,3-dimethylbutyl]-4-chromanone; (1'S,2R)-2-[(1',2'-O-Isopropylidene)dihydroxyethyl]-6-fluorochroman-4-one; Fluorinated Chromanone Derivative; Chiral Fluorochromanone Intermediate
EINECS	Contact for details

Quality Control

Every batch of (1’S,2R)-2-[(1’,2’-o-Isopropylidene)Dihydroxyethyl]-6-Fluorochroman-4-One is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and enantiomeric excess meet the exacting standards required for pharmaceutical development. A Certificate of Analysis (COA) detailing specifications such as assay (HPLC), chiral purity, and related substances is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.