Description

2-Propanesulfinamide,2-Methyl-n-[(4-Methylphenyl)Methylene]-,[S(R)]-(9Ci) is a high-purity chiral sulfinamide derivative, a critical building block in asymmetric synthesis. Its value lies in its role as a highly effective chiral auxiliary and ligand for the stereoselective construction of carbon-nitrogen and carbon-carbon bonds, enabling the production of enantiomerically pure pharmaceuticals and agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality chiral intermediates for complex synthetic routes.

Application

• Asymmetric Synthesis: Employed as a versatile chiral auxiliary in the stereoselective synthesis of amines, amino acids, and other nitrogen-containing compounds.
• Pharmaceutical Intermediates: A key precursor in the development of active pharmaceutical ingredients (APIs) requiring specific stereochemistry, particularly in CNS and antiviral drug candidates.
• Catalyst and Ligand Preparation: Used in the synthesis of chiral ligands for transition metal catalysis, facilitating enantioselective transformations like additions and reductions.
• Agrochemical Research: Serves as a building block for creating chiral active ingredients in herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Academic & Process R&D: A valuable tool for methodological development in organic chemistry laboratories and for scaling up enantioselective processes.
• Fine Chemical Manufacturing: Integral to the custom synthesis of complex, high-value specialty chemicals for various advanced material applications.

Basic Information

Product Name	2-Propanesulfinamide,2-Methyl-n-[(4-Methylphenyl)Methylene]-,[S(R)]-(9Ci)
CAS No.	796038-73-8
Molecular Formula	C12H17NOS
Molecular Weight	223.33 g/mol
Synonyms	(S)-2-Methyl-N-[(4-methylphenyl)methylene]propane-2-sulfinamide; (S)-2-Methyl-N-(p-tolylidene)propane-2-sulfinamide; (S)-tert-Butanesulfinamide p-tolualdimine; (S)-N-(4-Methylbenzylidene)-2-methylpropane-2-sulfinamide; (S)-N-(p-Tolylidene)-2-methylpropane-2-sulfinamide; (S,R)-2-Methyl-N-[(4-methylphenyl)methylene]propane-2-sulfinamide; Chiral Sulfinamide Auxiliary; p-Tolualdimine tert-Butylsulfinamide (S)
EINECS	Contact for details

Quality Control

Our production of 2-Propanesulfinamide,2-Methyl-n-[(4-Methylphenyl)Methylene]-,[S(R)]-(9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for sensitive asymmetric syntheses. Each lot is characterized by advanced analytical techniques including chiral HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect performance. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.