Description

1-Butanone,4,4-Difluoro-3-Hydroxy-1-Phenyl-,(3S)-(9Ci) is a chiral, fluorinated β-hydroxy ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals and agrochemicals, where its specific stereochemistry and fluorine atoms are crucial for modulating biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex, bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in routes targeting central nervous system (CNS) agents and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance lipophilicity and environmental stability.
• Asymmetric Catalysis Research: Serves as a valuable substrate or ligand precursor in the development and testing of new chiral catalysts and synthetic methodologies.
• Fine Chemical Building Block: Employed in custom synthesis and contract manufacturing for producing specialty chemicals with high added value.
• Material Science Precursor: Potential use in the synthesis of fluorinated organic materials and liquid crystals for electronic applications.

Basic Information

Product Name	1-Butanone,4,4-Difluoro-3-Hydroxy-1-Phenyl-,(3S)-(9Ci)
CAS No.	790222-41-2
Molecular Formula	C10H10F2O2
Molecular Weight	200.18 g/mol
Synonyms	(3S)-4,4-Difluoro-3-hydroxy-1-phenylbutan-1-one; (S)-4,4-Difluoro-3-hydroxy-1-phenylbutan-1-one; 4,4-Difluoro-3-hydroxy-1-phenyl-1-butanone, (3S)-; 1-Phenyl-4,4-difluoro-3-hydroxy-1-butanone, (S)-; 790222-41-2; (S)-4,4-Difluoro-3-hydroxybutyrophenone; (3S)-4,4-Difluoro-3-hydroxybutyrophenone
EINECS	Contact for details

Quality Control

Our 1-Butanone,4,4-Difluoro-3-Hydroxy-1-Phenyl-,(3S)-(9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.