Description

(4R)-6-(Propan-2-Yl)-3,4-Dihydro-2H-1-Benzopyran-4-Amine is a chiral amine derivative of a chromane scaffold, serving as a critical building block in advanced organic synthesis. This compound is valued for its structural complexity and stereochemical purity, enabling the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily required by research and development laboratories, pharmaceutical companies, and fine chemical manufacturers focused on creating new therapeutic agents and high-value specialty compounds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective synthesis to introduce the (4R)-amine functionality into complex molecules.
• Medicinal Chemistry Research: A versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fine Chemical Production: Serves as a starting material or intermediate in the multi-step synthesis of agrochemicals, flavors, and fragrances.
• Academic & Contract Research: Used in university and CRO settings for methodological development in organic chemistry and catalysis.

Basic Information

Product Name	(4R)-6-(Propan-2-Yl)-3,4-Dihydro-2H-1-Benzopyran-4-Amine
CAS No.	776293-94-8
Molecular Formula	C12H17NO
Molecular Weight	191.27 g/mol
Synonyms	(4R)-6-Isopropyl-3,4-dihydro-2H-chromen-4-amine; (4R)-6-Isopropylchroman-4-amine; (4R)-6-(1-Methylethyl)-3,4-dihydro-2H-1-benzopyran-4-amine; (R)-6-Isopropylchroman-4-amine; 4-Amino-6-isopropylchroman, (4R)-; 776293-94-8; UNII-6K7K8F0Q3K
EINECS	Contact for details

Quality Control

Our (4R)-6-(Propan-2-Yl)-3,4-Dihydro-2H-1-Benzopyran-4-Amine is produced under strict quality management systems to ensure batch-to-batch consistency and high stereochemical purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, NMR, and mass spectrometry for structural confirmation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.