Description

2-((4R,6S)-6-(Chloromethyl)-2,2-Dimethyl- 1,3-Dioxan-4-Yl)Acetic Acid is a high-purity, stereochemically defined chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters because it serves as a critical building block for the production of complex active pharmaceutical ingredients (APIs), particularly statin drugs, where its specific stereochemistry is essential for biological activity. Pharmaceutical R&D departments and fine chemical manufacturers need this material for developing and scaling up next-generation therapeutics that require precise molecular architecture.

Application

• Key Intermediate in Statin Synthesis: A crucial chiral precursor in the manufacturing of Atorvastatin, Rosuvastatin, and other HMG-CoA reductase inhibitors.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the discovery and optimization of new drug candidates targeting cholesterol metabolism.
• Process Chemistry & Scale-Up: Employed in pilot plants and commercial API production where high stereochemical purity is non-negotiable.
• Asymmetric Synthesis: Serves as a valuable starting material or intermediate for constructing other complex, stereogenic molecules in fine chemical synthesis.
• Reference Standard: Used as an analytical standard in quality control laboratories to ensure the purity and identity of final API batches.

Basic Information

Product Name	2-((4R,6S)-6-(Chloromethyl)-2,2-Dimethyl- 1,3-Dioxan-4-Yl)Acetic Acid
CAS No.	775571-58-9
Molecular Formula	C10H17ClO4
Molecular Weight	236.69 g/mol
Synonyms	(4R,6S)-6-(Chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid; (4R-cis)-6-(Chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid; Atorvastatin Intermediate; Rosuvastatin Intermediate; Statin Side Chain Intermediate; (4R,6S)-6-(Chloromethyl)-2,2-dimethyl-1,3-dioxan-4-ylacetic Acid; 2-[(4R,6S)-6-(Chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetic Acid
EINECS	Contact for details

Quality Control

Our production of 2-((4R,6S)-6-(Chloromethyl)-2,2-Dimethyl- 1,3-Dioxan-4-Yl)Acetic Acid adheres to stringent quality management systems, ensuring batch-to-batch consistency suitable for cGMP manufacturing. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We support compliance with major pharmacopoeial standards (USP, EP) and regulatory frameworks (ICH Q7, REACH) to meet the exacting requirements of the global pharmaceutical supply chain.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.