Description

5-Chloro-2-(Difluoromethoxy)Benzoic Acid is a high-value, multi-functional aromatic carboxylic acid derivative distinguished by its chloro and difluoromethoxy substituents. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting metabolic and inflammatory pathways.
• Agrochemical Synthesis: Used as a precursor in the development of modern herbicides and fungicides, where the difluoromethoxy group enhances biological activity and stability.
• Ligand & Catalyst Development: Serves as a functionalized backbone for creating novel ligands in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers and liquid crystals, where its aromatic core and halogenated groups modify material properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, esterifications, and amide bond formations to introduce the benzoic acid moiety with specific halogenation.

Basic Information

Product Name	5-Chloro-2-(Difluoromethoxy)Benzoic Acid
CAS No.	773869-44-6
Molecular Formula	C8H5ClF2O3
Molecular Weight	222.57 g/mol
Synonyms	5-Chloro-2-(difluoromethoxy)benzoic acid; Benzoic acid, 5-chloro-2-(difluoromethoxy)-; 2-(Difluoromethoxy)-5-chlorobenzoic acid; 5-Chloro-2-difluoromethoxybenzoic acid; 773869-44-6; DFMOB-CA; 5-Cl-2-DFMOBA
EINECS	Contact for details

Quality Control

Our production of 5-Chloro-2-(Difluoromethoxy)Benzoic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure compliance with pharmaceutical intermediate standards. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.