Description

((2S,3R)-4-(4-Chloro-1,1,2,2,3,3,4,4-Octafluorobutylsulfonyl)-5-Phenyl-3-(Pyridin-4-Yl)-2,3-Dihydrofuran-2-Yl)(Phenyl)Methanone is a high-value, structurally complex fluorinated organic compound designed for advanced synthetic applications. This compound matters as a sophisticated building block or intermediate in the development of novel active pharmaceutical ingredients (APIs) and specialty materials, where its unique perfluorinated alkylsulfonyl and heterocyclic motifs impart specific electronic and steric properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating next-generation molecules with targeted functionalities.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the research and synthesis of novel drug candidates, particularly in therapeutic areas requiring complex, fluorinated molecular architectures.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the fluorine atoms and sulfonyl group can enhance biological activity, stability, and environmental profile.
• Material Science Precursor: Acts as a monomer or functional additive in the synthesis of specialty polymers, liquid crystals, or organic electronic materials due to its rigid, multi-ring structure and fluorinated side chain.
• Catalyst or Ligand Development: The pyridine and carbonyl functionalities make it a candidate for modification into chiral ligands or organocatalysts for asymmetric synthesis.
• Chemical Biology Probe: Utilized in academic and industrial research to create molecular probes for studying enzyme mechanisms or protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific, multi-step synthetic projects requiring high-purity, complex intermediates.

Basic Information

Product Name	((2S,3R)-4-(4-Chloro-1,1,2,2,3,3,4,4-Octafluorobutylsulfonyl)-5-Phenyl-3-(Pyridin-4-Yl)-2,3-Dihydrofuran-2-Yl)(Phenyl)Methanone
CAS No.	771491-63-5
Molecular Formula	C26H16ClF8NO4S
Molecular Weight	617.91 g/mol
Synonyms	(2S,3R)-4-[(4-Chloro-1,1,2,2,3,3,4,4-octafluorobutyl)sulfonyl]-5-phenyl-3-(4-pyridinyl)-2,3-dihydro-2-furanylphenylmethanone; (2S,3R)-4-(4-Chloro-octafluorobutanesulfonyl)-5-phenyl-3-(pyridin-4-yl)-2,3-dihydrofuran-2-yl)(phenyl)methanone; Phenyl((2S,3R)-4-(4-chloro-1,1,2,2,3,3,4,4-octafluorobutylsulfonyl)-5-phenyl-3-(pyridin-4-yl)-2,3-dihydrofuran-2-yl)methanone; CAS 771491-63-5; Fluorinated Dihydrofuranone Sulfone Intermediate; Chiral Fluorinated Building Block 771491-63-5.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each batch, documenting identity, purity, and impurity profiles. We support development and commercial projects with quality standards tailored to client requirements, including potential compliance with ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is sensitive to light and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.