Description

6-Chloro-Chroman-4-Ylamine is a versatile chiral amine building block of significant interest in advanced organic synthesis. Its core value lies in its chroman scaffold and functionalized amine group, which are pivotal for constructing complex molecular architectures with specific stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and other therapeutic areas.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and insecticides, leveraging its bioactive chroman structure.
• Asymmetric Catalysis: Used as a ligand precursor or chiral auxiliary in catalytic reactions to induce enantioselectivity.
• Material Science: A building block for specialty polymers and advanced organic materials requiring specific optical or electronic properties.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for biological target validation.

Basic Information

Product Name	6-Chloro-Chroman-4-Ylamine
CAS No.	765880-61-3
Molecular Formula	C9H10ClNO
Molecular Weight	183.63 g/mol
Synonyms	4-Amino-6-chlorochroman; 6-Chloro-3,4-dihydro-2H-1-benzopyran-4-amine; 6-Chloro-4-aminochroman; 6-Chloro-2,3-dihydro-4H-1-benzopyran-4-amine; 6-Chloro-4-chromanamine; (4-Amino-6-chloro-3,4-dihydro-2H-chromen); 6-Chloro-4-aminodihydrobenzopyran
EINECS	Contact for details

Quality Control

Our 6-Chloro-Chroman-4-Ylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide Certificates of Analysis (COA) with detailed specifications for trace metals, residual solvents, and related substances, ensuring compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e. (Specific enantiomer available)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.