Description

(S)-tert-Butyl 3-(2-Ethoxy-2-Oxoethyl)Morpholine-4-Carboxylate is a high-value chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of novel therapeutics. It is essential for research institutions and manufacturers in the pharmaceutical and fine chemical industries requiring high-purity, stereochemically defined intermediates for process development and scale-up.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and antiviral targets.
• Asymmetric Synthesis: Used as a building block in stereoselective reactions to construct morpholine-containing scaffolds with defined chirality.
• Process Chemistry & Scale-Up: Serves as a critical intermediate in the research, development, and commercial manufacturing of new chemical entities (NCEs).
• Medicinal Chemistry Research: Enables the exploration of structure-activity relationships (SAR) in drug discovery programs by providing a versatile, functionalized morpholine core.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) producing bespoke intermediates for client projects.

Basic Information

Product Name	(S)-tert-Butyl 3-(2-Ethoxy-2-Oxoethyl)Morpholine-4-Carboxylate
CAS No.	761460-04-2
Molecular Formula	C13H23NO5
Molecular Weight	273.33 g/mol
Synonyms	(S)-tert-Butyl 3-(2-ethoxy-2-oxoethyl)morpholine-4-carboxylate; 4-[(1,1-Dimethylethoxy)carbonyl]-3-(2-ethoxy-2-oxoethyl)morpholine, (S)-; (S)-3-(2-Ethoxy-2-oxoethyl)morpholine-4-carboxylic acid tert-butyl ester; tert-Butyl (S)-3-(2-ethoxy-2-oxoethyl)morpholine-4-carboxylate; (S)-Boc-3-(2-ethoxy-2-oxoethyl)morpholine; (S)-N-Boc-3-(ethoxycarbonylmethyl)morpholine
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 3-(2-Ethoxy-2-Oxoethyl)Morpholine-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.