Description

4-Trifluoromethyl-2H-Pyridazin-3-One is a high-value fluorinated heterocyclic building block essential for advanced organic synthesis. This compound matters as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethyl group imparts desirable metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate this privileged scaffold into new molecular entities.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the pyridazinone core contributes to biological activity.
• Material Science Research: Serves as a precursor for the development of advanced fluorinated materials, including liquid crystals and organic electronic components.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards for client-specific molecules.

Basic Information

Item	Details
Product Name	4-Trifluoromethyl-2H-Pyridazin-3-One
CAS No.	749258-95-5
Molecular Formula	C5H3F3N2O
Molecular Weight	164.09 g/mol
Synonyms	4-(Trifluoromethyl)-2H-pyridazin-3-one; 4-(Trifluoromethyl)-3(2H)-pyridazinone; 4-Trifluoromethyl-3(2H)-pyridazinone; 3-Hydroxy-4-(trifluoromethyl)pyridazine; 4-Trifluoromethylpyridazin-3-ol; 749258-95-5; 4-Trifluoromethyl-2H-pyridazin-3-one
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethyl-2H-Pyridazin-3-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting research and development standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee reproducible results in your synthetic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.