Description

(E)-2-(4-(Cyclopropylsulfonyl)Phenyl)-3-(Tetrahydro-2H-Pyran-4-Yl)Acrylic Acid is a high-purity, non-racemic chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters for its role as a sophisticated building block in the development of novel active pharmaceutical ingredients (APIs), particularly those targeting specific biological pathways. Pharmaceutical R&D teams and fine chemical manufacturers need this material for its precise stereochemistry and functional groups, which are critical for constructing complex molecular architectures with high therapeutic potential.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for small molecule therapeutics.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) requiring specific (E)-configured acrylic acid derivatives.
• Medicinal Chemistry Research: Serves as a valuable scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed in reactions that require a defined stereocenter, contributing to the production of enantiomerically pure compounds.
• Chemical Biology Probes: Can be utilized in the design and synthesis of molecular probes for investigating biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material or intermediate for CDMOs (Contract Development and Manufacturing Organizations) serving the pharmaceutical industry.

Basic Information

Product Name	(E)-2-(4-(Cyclopropylsulfonyl)Phenyl)-3-(Tetrahydro-2H-Pyran-4-Yl)Acrylic Acid
CAS No.	745052-98-6
Molecular Formula	C17H20O4S
Molecular Weight	320.40 g/mol
Synonyms	(2E)-2-[4-(Cyclopropylsulfonyl)phenyl]-3-(oxan-4-yl)prop-2-enoic acid; 2-(4-(Cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylic acid; (E)-3-(Tetrahydro-2H-pyran-4-yl)-2-[4-(cyclopropylsulfonyl)phenyl]acrylic acid; 745052-98-6; (E)-2-(4-(Cyclopropylsulfonyl)phenyl)-3-(tetrahydropyran-4-yl)acrylic acid; (E)-2-(4-(Cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)-2-propenoic acid
EINECS	Contact for details

Quality Control

Our (E)-2-(4-(Cyclopropylsulfonyl)Phenyl)-3-(Tetrahydro-2H-Pyran-4-Yl)Acrylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP (current Good Manufacturing Practice) intermediate applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.