Description

Ethyl 2-(4-(cyclopropylthio)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylate is a high-purity, advanced pharmaceutical intermediate characterized by its unique molecular architecture combining cyclopropylthio, phenyl, and tetrahydropyran moieties. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) where precise stereochemistry and functional group compatibility are paramount. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Process Chemistry Development: Serves as a critical intermediate for scaling up API synthesis from laboratory to pilot and commercial production.
• Custom Synthesis: Employed by fine chemical manufacturers for producing specialized compounds under contract research and manufacturing (CRAM) agreements.
• Academic Research: Utilized in university and institutional labs for exploring new organic reactions and synthetic methodologies.

Basic Information

Product Name	Ethyl 2-(4-(Cyclopropylthio)Phenyl)-3-(Tetrahydro-2H-Pyran-4-Yl)Acrylate
CAS No.	745052-95-3
Molecular Formula	C19H24O3S
Molecular Weight	332.46 g/mol
Synonyms	Ethyl (2E)-2-[4-(cyclopropylsulfanyl)phenyl]-3-(oxan-4-yl)prop-2-enoate; Ethyl (E)-2-(4-(Cyclopropylthio)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylate; 745052-95-3; Acrylic acid, 2-[4-(cyclopropylthio)phenyl]-3-(tetrahydro-2H-pyran-4-yl)-, ethyl ester, (2E)-; Ethyl 2-(4-(Cyclopropylthio)Phenyl)-3-(Tetrahydropyran-4-yl)propenoate
EINECS	Contact for details

Quality Control

Our Ethyl 2-(4-(cyclopropylthio)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.