Description

2-(4-Cyclopropanesulfonyl-Phenyl)-3-(Tetrahydro-Pyran-4-Yl)-Propionic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique molecular architecture combining cyclopropane, sulfonyl, and tetrahydropyran moieties. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), offering a sophisticated building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas requiring complex, functionalized carboxylic acid derivatives.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of new drug candidates, especially for central nervous system (CNS) and anti-inflammatory targets.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to introduce the 2-(4-cyclopropanesulfonylphenyl)propionic acid pharmacophore into more complex molecules.
• API Development: Integral in the process development and scale-up for potential active pharmaceutical ingredients requiring this specific carboxylic acid derivative.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical industry.

Basic Information

Product Name	2-(4-Cyclopropanesulfonyl-Phenyl)-3-(Tetrahydro-Pyran-4-Yl)-Propionic Acid
CAS No.	745052-93-1
Molecular Formula	C17H22O5S
Molecular Weight	338.42 g/mol
Synonyms	2-[4-(Cyclopropylsulfonyl)phenyl]-3-(oxan-4-yl)propanoic acid; 2-(4-Cyclopropanesulfonylphenyl)-3-(tetrahydro-2H-pyran-4-yl)propanoic Acid; 3-(Tetrahydro-2H-pyran-4-yl)-2-[4-(cyclopropylsulfonyl)phenyl]propionic Acid; 745052-93-1; Propionic acid, 2-[4-(cyclopropylsulfonyl)phenyl]-3-(tetrahydro-2H-pyran-4-yl)-; 2-(4-Cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4-yl)propionic acid
EINECS	Contact for details

Quality Control

Our 2-(4-Cyclopropanesulfonyl-Phenyl)-3-(Tetrahydro-Pyran-4-Yl)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent chemical identity, meeting the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.