Description

4-Trifluoromethylbenzylzinc Chloride is a versatile organozinc reagent, a critical building block for the formation of carbon-carbon bonds in complex organic synthesis. Its value lies in its ability to introduce the 4-(trifluoromethyl)benzyl group with high selectivity and functional group tolerance, a key structural motif in advanced materials and pharmaceuticals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorinated aromatic systems into their target molecules.

Application

• As a key nucleophilic reagent in Negishi cross-coupling reactions for constructing biaryl and alkyl-aryl bonds.
• Intermediate in the synthesis of active pharmaceutical ingredients (APIs) containing the trifluoromethylbenzyl pharmacophore.
• Building block for advanced agrochemicals, leveraging the properties of fluorine to enhance biological activity and metabolic stability.
• Precursor in material science for creating fluorinated liquid crystals, polymers, and organic electronic materials.
• Used in medicinal chemistry for the parallel synthesis and library generation of drug-like compounds for screening.
• Reagent for the functionalization of complex molecules in late-stage diversification strategies.

Basic Information

Product Name	4-Trifluoromethylbenzylzinc Chloride
CAS No.	738580-34-2
Molecular Formula	C8H6ClF3Zn
Molecular Weight	259.96 g/mol
Synonyms	(4-(Trifluoromethyl)benzyl)zinc chloride; 1-(Chlorozinomethyl)-4-(trifluoromethyl)benzene; 4-(Trifluoromethyl)benzylzinc chloride; α-(Trifluoromethyl)benzylzinc chloride; (4-Trifluoromethylphenyl)methylzinc chloride; Zinc, chloromethyl[4-(trifluoromethyl)phenyl]-; Trifluoromethylbenzylzinc chloride solution
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethylbenzylzinc Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including titration for zinc content and NMR/Gas Chromatography (GC) analysis for identity and purity, to ensure consistency and reliability for your synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, well-ventilated area. Due to its hygroscopic and pyrophoric nature, the reagent must be handled under inert conditions using appropriate techniques.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration	0.5 M in Tetrahydrofuran (THF)
Assay (Titration)	≥ 95%
Identity (NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.