Description

2,3,5,6-Tetramethylphenylzinc Iodide is a highly reactive organozinc reagent, specifically an arylzinc halide, used in advanced organic synthesis. This compound is valued for its role as a key coupling partner in cross-coupling reactions, enabling the efficient construction of complex, sterically hindered aromatic systems. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional molecules.

Application

• Cross-Coupling Reactions: A crucial reagent in Negishi, Kumada, and related palladium-catalyzed cross-couplings for C-C bond formation.
• Pharmaceutical Intermediate Synthesis: Used to introduce the sterically demanding 2,3,5,6-tetramethylphenyl group into drug candidates and bioactive molecules.
• Agrochemical Development: Employed in the synthesis of novel herbicides, fungicides, and insecticides with tailored properties.
• Materials Science Research: Facilitates the creation of specialized ligands for catalysts and building blocks for organic electronic materials.
• Fine Chemical Manufacturing: Serves as a precise arylating agent in the multi-step synthesis of complex fragrance and flavor compounds.
• Academic & R&D Laboratories: A valuable tool for methodological development in organometallic chemistry and new synthetic pathway exploration.

Basic Information

Product Name	2,3,5,6-Tetramethylphenylzinc Iodide
CAS No.	737797-44-3
Molecular Formula	C10H13IZn
Molecular Weight	325.50 g/mol
Synonyms	(2,3,5,6-Tetramethylphenyl)zinc iodide; Zinc, (2,3,5,6-tetramethylphenyl)iodo-; Tetramethylphenylzinc iodide; Duryizinc iodide; 2,3,5,6-Tetramethylbenzenylzinc iodide; ArZnI (where Ar = 2,3,5,6-Tetramethylphenyl); TMPhZnI
EINECS	Contact for details

Quality Control

Every batch of 2,3,5,6-Tetramethylphenylzinc Iodide is manufactured and handled under strict inert atmosphere conditions to ensure stability and reactivity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing assay, purity, and solution concentration are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. This material is hygroscopic (moisture-sensitive) and air-sensitive; all handling must be performed using standard Schlenk line or glovebox techniques to prevent decomposition.

Specification

Item	Specification
Appearance	Solution (typically in THF or Ether)
Identification (NMR)	Conforms to structure
Assay (Titration)	0.5 M in solvent (or as specified)
Purity (HPLC)	≥ 95% (by GC/HPLC of derived product)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.