Description

3,4-Difluorophenylzinc Bromide is a highly reactive organozinc reagent, specifically a functionalized arylzinc halide. This compound is a critical building block in modern synthetic organic chemistry, enabling the efficient and selective formation of carbon-carbon bonds. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of complex fluorinated aromatic compounds.

Application

• Pharmaceutical Intermediate: Key reagent in Negishi cross-coupling reactions for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing difluorophenyl motifs.
• Agrochemical Synthesis: Used in the construction of advanced herbicide and pesticide molecules where the 3,4-difluorophenyl group imparts specific biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis and other catalytic processes.
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, and polymers for electronic and optical applications.
• Custom Chemical Synthesis: Essential for contract research organizations (CROs) and custom synthesis laboratories building bespoke fluorinated aromatic structures for client projects.

Basic Information

Product Name	3,4-Difluorophenylzinc Bromide
CAS No.	737797-28-3
Molecular Formula	C6H3F2ZnBr
Molecular Weight	244.29 g/mol
Synonyms	Zinc, bromo(3,4-difluorophenyl)-; (3,4-Difluorophenyl)zinc bromide; 3,4-Difluorophenylzinc bromide solution; 1,2-Difluoro-4-(bromozincio)benzene; Bromo(3,4-difluorophenyl)zinc; 3,4-DFP-ZnBr
EINECS	Contact for details

Quality Control

Every batch of 3,4-Difluorophenylzinc Bromide is manufactured and handled under strict inert atmosphere conditions to ensure reagent integrity. Our products undergo rigorous quality testing to ensure compliance with industry standards for research and process chemistry. Certificates of Analysis (COA) detailing assay, titration results, and solvent concentration are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. This material is hygroscopic (moisture-sensitive) and air-sensitive; all handling and aliquoting must be performed using standard Schlenk line or glovebox techniques to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (NMR)	Conforms to structure
Assay (Titration)	0.5 M in THF (Typical)
Purity (GC)	≥ 95% (on metal basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.