Description

2,5-Dimethylbenzylzinc Chloride is a versatile organozinc reagent, a key building block in modern synthetic organic chemistry. Its value lies in enabling highly selective carbon-carbon bond formation, particularly in Negishi cross-coupling reactions, which are crucial for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require precise and efficient synthetic pathways.

Application

• Pharmaceutical Intermediate Synthesis: A critical reagent for constructing complex, functionalized aromatic and heterocyclic scaffolds found in active pharmaceutical ingredients (APIs).
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides that require specific, substituted benzyl structures.
• Ligand and Catalyst Preparation: Serves as a precursor for the synthesis of specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Advanced Material Research: Employed in the creation of organic electronic materials, liquid crystals, and polymers with tailored properties.
• Negishi Cross-Coupling Reactions: Primarily used for the palladium-catalyzed coupling with various organic electrophiles to form new C-C bonds with high fidelity.
• Academic and R&D Laboratories: A valuable tool for methodological development and the exploration of new synthetic routes in organic chemistry.

Basic Information

Product Name	2,5-Dimethylbenzylzinc Chloride
CAS No.	737797-24-9
Molecular Formula	C9H11ClZn
Molecular Weight	219.99 g/mol
Synonyms	(2,5-Dimethylphenyl)methylzinc chloride; Zinc, chloromethyl(2,5-dimethylphenyl)-; 2,5-Dimethylbenzylzinc chloride solution; Benzene, 1-methyl-4-(chlorozinciomethyl)-2-methyl-; (2,5-Xylylmethyl)zinc chloride; Organozinc reagent 737797-24-9; Chloro(2,5-dimethylbenzyl)zinc
EINECS	Contact for details

Quality Control

Our 2,5-Dimethylbenzylzinc Chloride is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm identity, concentration (typically supplied as a solution in THF or ether), and the absence of deleterious impurities. A comprehensive Certificate of Analysis (COA) detailing assay (by titration), solvent content, and zinc concentration is provided with every shipment to support your quality assurance and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and easily oxidized (store under inert atmosphere). For optimal stability, store the sealed reagent bottle under a dry, inert gas (argon or nitrogen) atmosphere at 2-8°C. Allow the container to reach room temperature before opening to minimize moisture ingress. Use in a dry, inert atmosphere glovebox or with standard Schlenk line techniques.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (IR)	Conforms to structure
Assay (Zinc content)	0.5 M in THF (or as specified)
Purity (by NMR)	≥ 95%
Solvent (Residual)	By GC

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.