Description

2,3-Dimethoxybenzylzinc Chloride is an organozinc reagent, specifically a benzylzinc halide, widely used in organic synthesis for the formation of carbon-carbon bonds. Its value lies in its ability to act as a stable and versatile nucleophile in cross-coupling reactions, such as Negishi coupling, enabling the efficient introduction of the 2,3-dimethoxybenzyl moiety into complex molecular frameworks. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require high-purity building blocks for constructing active pharmaceutical ingredients (APIs), ligands, and functional organic molecules.

Application

• Key intermediate in Negishi cross-coupling reactions for the synthesis of complex biaryl and alkyl-aryl compounds.
• Building block for pharmaceutical research, particularly in constructing drug candidates containing dimethoxyphenyl groups.
• Precursor in the development of specialty chemicals and fine chemicals for agrochemical applications.
• Used in material science for the synthesis of organic ligands and functional polymers.
• Reagent in methodology development for new organometallic catalytic cycles.
• Critical for process chemistry in scaling up the production of target molecules under mild conditions.

Basic Information

Product Name	2,3-Dimethoxybenzylzinc Chloride
CAS No.	737797-22-7
Molecular Formula	C9H11ClO2Zn
Molecular Weight	251.99 g/mol
Synonyms	(2,3-Dimethoxyphenyl)methylzinc Chloride; Zinc, chloromethylbis(2,3-dimethoxyphenyl)-; 2,3-Dimethoxybenzyl Zinc Chloride; (2,3-Dimethoxybenzyl)zinc Chloride; Benzylzinc Chloride, 2,3-dimethoxy-; 1-(Chlorozinomethyl)-2,3-dimethoxybenzene
EINECS	Contact for details

Quality Control

Our 2,3-Dimethoxybenzylzinc Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm identity, purity, and concentration, typically supplied as a solution in tetrahydrofuran (THF) or other suitable solvents. A comprehensive Certificate of Analysis (COA) detailing assay (by titration), solvent content, and impurity profile is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and easily oxidized; ensure containers are sealed immediately after use to exclude moisture and air.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (IR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (Zinc basis)	≥ 95%
Solvent Content	Balance (typically THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.