Description

2,5-Dichlorobenzylzinc Chloride is a highly reactive organozinc reagent, specifically a benzylzinc halide derivative. This compound is a critical building block in modern synthetic organic chemistry, enabling the efficient and selective introduction of the 2,5-dichlorobenzyl group into complex molecular frameworks. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for cross-coupling reactions and nucleophilic additions.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing complex drug molecules, particularly in Negishi and other transition-metal-catalyzed cross-coupling reactions.
• Agrochemical Active Ingredient Development: Used in the research and production of herbicides, fungicides, and insecticides that incorporate the dichlorobenzyl moiety.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of novel organic electronic materials, liquid crystals, and polymers with tailored properties.
• Fine Chemical and Flavor/Fragrance Synthesis: Facilitates the production of high-value specialty chemicals through precise carbon-carbon bond formation.
• Academic and R&D Laboratories: An essential tool for methodological development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	2,5-Dichlorobenzylzinc Chloride
CAS No.	737797-20-5
Molecular Formula	C7H5Cl3Zn
Molecular Weight	260.83 g/mol
Synonyms	(2,5-Dichlorobenzyl)zinc chloride; Zinc, (2,5-dichlorophenyl)methylchloro-; 2,5-Dichlorobenzylzinc chloride solution; (2,5-Dichlorobenzyl)chlorozinc; Benzene, 1-(chlorozinomethyl)-2,5-dichloro-; Organozinc reagent 737797-20-5
EINECS	Contact for details

Quality Control

Our 2,5-Dichlorobenzylzinc Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm identity, purity, and solution concentration (typically supplied in THF or other ethereal solvents). Certificates of Analysis (COA) detailing assay (by titration or ICP), residual moisture, and solvent content are provided. We adhere to cGMP principles where applicable to support our customers in regulated industry segments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at temperatures between 2°C and 8°C. This material is hygroscopic (moisture-sensitive) and easily oxidized; exposure to air or moisture must be minimized to preserve reactivity. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (IR/NMR)	Conforms to structure
Assay (as Zn)	0.5 M in THF (or as specified)
Purity (HPLC/GC)	≥ 95% (by GC of derived product)
Solvent	Specified (e.g., Tetrahydrofuran, Diethyl ether)
Water Content (Karl Fischer)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.