Description

2-Fluoro-4-Methylphenylzinc Bromide is a highly reactive organozinc reagent used as a key building block in advanced organic synthesis. Its value lies in enabling efficient carbon-carbon bond formation, specifically through cross-coupling reactions, which is critical for constructing complex molecular architectures. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require precise and reliable synthetic intermediates.

Application

• Pharmaceutical Intermediate: A crucial reagent for the synthesis of active pharmaceutical ingredients (APIs), particularly in constructing fluorinated and methyl-substituted aromatic rings.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the 2-fluoro-4-methylphenyl moiety imparts specific biological activity.
• Material Science Research: Serves as a precursor for creating functionalized organic molecules used in organic light-emitting diodes (OLEDs) and liquid crystals.
• Cross-Coupling Reactions: Primarily employed in Negishi coupling reactions with aryl or vinyl halides to form biaryl structures, a fundamental transformation in medicinal chemistry.
• Chemical Library Development: Used in high-throughput and parallel synthesis for generating diverse compound libraries for drug discovery screening.
• Fine Chemical Production: Acts as a specialized intermediate in the custom synthesis of complex, high-value fine chemicals and flavors/fragrances.

Basic Information

Product Name	2-Fluoro-4-Methylphenylzinc Bromide
CAS No.	737797-14-7
Molecular Formula	C7H6BrFZn
Molecular Weight	246.41 g/mol
Synonyms	2-Fluoro-4-methylphenylzinc bromide; (2-Fluoro-4-methylphenyl)zinc bromide; Zinc, bromo(2-fluoro-4-methylphenyl)-; Bromo(2-fluoro-4-methylphenyl)zinc; 2-Fluoro-p-tolylzinc bromide; 4-Methyl-2-fluorophenylzinc bromide; 737797-14-7
EINECS	Contact for details

Quality Control

Every batch of our 2-Fluoro-4-Methylphenylzinc Bromide is produced and tested under stringent quality management protocols to ensure consistency and reliability for your critical synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity, concentration, and impurity profiles. Our commitment to cGMP and ISO 9001 standards underpins our focus on supply chain integrity and product traceability.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, and well-ventilated place. Due to its moisture-sensitive and easily oxidized nature, the container must be kept sealed under positive pressure of inert gas and allowed to reach room temperature before opening to prevent condensation and degradation.

Specification

Item	Specification
Appearance	Solution (typically in THF or ether)
Identification (NMR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (GC/HPLC)	≥ 95% (organozinc content)
Water Content (KF)	< 500 ppm
Color	Colorless to pale yellow

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.