Description

(R)-8-Fluorochroman-4-Amine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its enantiomeric purity and functionalized chroman scaffold, which is crucial for the development of targeted bioactive molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, particularly within central nervous system (CNS) and cardiovascular drug discovery programs.

Application

• Key chiral intermediate in the research and development of new pharmaceutical entities.
• Building block for the synthesis of potential serotonin and norepinephrine reuptake inhibitors (SNRIs).
• Precursor in the preparation of fluorinated analogs for structure-activity relationship (SAR) studies.
• Starting material for the development of ligands targeting G-protein coupled receptors (GPCRs).
• Used in asymmetric synthesis to introduce the chiral chroman-4-amine moiety into complex molecules.
• Reference standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	(R)-8-Fluorochroman-4-Amine Hydrochloride
CAS No.	730980-49-1
Molecular Formula	C9H11FNO•HCl
Molecular Weight	203.65 g/mol (Free base: 167.19 g/mol)
Synonyms	(R)-8-Fluorochroman-4-amine HCl; (4R)-8-Fluoro-3,4-dihydro-2H-1-benzopyran-4-amine hydrochloride; (R)-8-Fluoro-3,4-dihydro-2H-chromen-4-amine hydrochloride; 8-Fluoro-4-chromanamine hydrochloride, (R)-; (R)-8-Fluorochroman-4-ylamine hydrochloride; 730980-49-1; (R)-4-Amino-8-fluorochroman hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-8-Fluorochroman-4-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm enantiomeric excess (ee) and standard pharmacopeial methods for identity, purity, and impurity profiling. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.