Description

(R)-6-Methylchroman-4-Amine Hydrochloride CAS NO 730980-47-9 is a high-purity chiral amine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a stereochemically defined scaffold essential for creating molecules with specific biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents and fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Synthesis: Utilized as a precursor or resolving agent in catalytic asymmetric reactions to construct complex, enantiomerically pure molecules.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis for lead optimization in drug discovery programs.
• Fine Chemical Production: Serves as a specialized intermediate in the custom synthesis of agrochemicals, flavors, and fragrances requiring specific stereochemistry.
• Biochemical Tool: Potential use in developing enzyme inhibitors or receptor ligands for biochemical and pharmacological research.

Basic Information

Product Name	(R)-6-Methylchroman-4-Amine Hydrochloride
CAS No.	730980-47-9
Molecular Formula	C10H14ClNO
Molecular Weight	199.68 g/mol
Synonyms	(R)-6-Methyl-3,4-dihydro-2H-1-benzopyran-4-amine hydrochloride; (4R)-6-Methyl-3,4-dihydro-2H-chromen-4-amine hydrochloride; (R)-4-Amino-6-methylchroman hydrochloride; (R)-6-Methyl-4-aminochroman hydrochloride; 6-Methylchroman-4-amine hydrochloride, (R)-; (R)-Toloxatone intermediate; Chroman-4-amine, 6-methyl-, (4R)-, hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-6-Methylchroman-4-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.