Description

2-(4-Chlorophenyl)-2,2-Difluoroethan-1-Amine is a high-purity, fluorinated aromatic amine building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a chlorophenyl ring and a difluoroethylamine moiety, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Serves as a critical building block in the research and production of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the difluoroamine group.
• Ligand & Catalyst Development: Used in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs), where the amine group facilitates coordination.
• Material Science Research: Employed in the creation of advanced polymers and functional materials, where the incorporation of fluorine atoms can enhance thermal stability, chemical resistance, and surface properties.
• Fluorine Chemistry Studies: An important compound for academic and industrial research focused on understanding and applying the unique effects of fluorine substitution in organic molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific, multi-step synthetic routes for proprietary compounds.

Basic Information

Item	Details
Product Name	2-(4-Chlorophenyl)-2,2-Difluoroethan-1-Amine
CAS No.	730913-16-3
Molecular Formula	C8H8ClF2N
Molecular Weight	191.60 g/mol
Synonyms	2-(4-Chlorophenyl)-2,2-difluoroethanamine; 1-(4-Chlorophenyl)-2,2-difluoroethylamine; 4-Chloro-α,α-difluorophenethylamine; 2,2-Difluoro-2-(4-chlorophenyl)ethanamine; 730913-16-3; p-Chloro-α,α-difluorophenethylamine
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Chlorophenyl)-2,2-Difluoroethan-1-Amine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, and NMR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.