Description

3-[(Prop-2-Ynylamino)Sulfonyl]Benzoic Acid is a specialized organic building block featuring a benzoic acid core functionalized with a sulfonamide linker and a terminal alkyne group. This unique molecular architecture makes it a valuable intermediate for the synthesis of more complex molecules, particularly in pharmaceutical research and advanced material science. It is primarily sought by R&D chemists and process development scientists working in medicinal chemistry and chemical biology.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially those targeting enzymes via sulfonamide inhibition.
• Click Chemistry Reagent: The terminal alkyne group enables participation in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and polymer synthesis.
• Proteolysis-Targeting Chimera (PROTAC) Development: Used in constructing linker components that connect E3 ligase ligands to target protein binders.
• Chemical Biology Probe Synthesis: Serves as a precursor for creating activity-based probes to study enzyme function and localization.
• Material Science Research: Incorporated into monomers for the development of functional polymers with specific surface properties.
• Agrochemical Research: Intermediate in the development of novel herbicides or fungicides containing sulfonamide motifs.

Basic Information

Item	Details
Product Name	3-[(Prop-2-Ynylamino)Sulfonyl]Benzoic Acid
CAS No.	725221-36-3
Molecular Formula	C10H9NO4S
Molecular Weight	239.25 g/mol
Synonyms	3-[(Prop-2-yn-1-ylamino)sulfonyl]benzoic acid; 3-[(2-Propynylamino)sulfonyl]benzoic Acid; Benzoic acid, 3-[(2-propynylamino)sulfonyl]-; 3-(Prop-2-ynylsulfamoyl)benzoic acid; 3-(Prop-2-yn-1-ylsulfamoyl)benzoic acid; 3-(Prop-2-ynylaminosulfonyl)benzoic acid; 3-(Prop-2-ynylsulfamoyl)benzoic acid; 725221-36-3
EINECS	Contact for details

Quality Control

Every batch of 3-[(Prop-2-Ynylamino)Sulfonyl]Benzoic Acid is produced and tested under strict quality management protocols to ensure consistency and purity for research applications. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing all specifications is available with each shipment and upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.