Description

2,4,6-Trimethylphenylzinc Iodide is a versatile organozinc reagent, a key building block in modern synthetic chemistry. Its value lies in its ability to facilitate efficient carbon-carbon bond formation, particularly in cross-coupling reactions, enabling the synthesis of complex organic molecules. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries seeking reliable and high-purity intermediates.

Application

• Pharmaceutical Intermediate Synthesis: A crucial reagent for constructing complex drug molecules, especially in Negishi and other transition-metal-catalyzed cross-coupling reactions.
• Agrochemical Development: Used in the synthesis of novel active ingredients for crop protection agents, where the mesityl group can impart desirable steric and electronic properties.
• Advanced Material Precursor: Serves as a building block for creating organic ligands, functionalized polymers, and liquid crystals with tailored properties.
• Organic Synthesis Research: Enables the introduction of the 2,4,6-trimethylphenyl (mesityl) group into target molecules, a valuable moiety for studying steric effects and stabilizing reactive centers.
• Catalyst and Ligand Preparation: Employed in the synthesis of specialized organometallic catalysts and phosphine ligands used in asymmetric synthesis.
• Fine Chemical Manufacturing: Provides a reliable pathway for the production of specialty chemicals and high-value intermediates on a commercial scale.

Basic Information

Product Name	2,4,6-Trimethylphenylzinc Iodide
CAS No.	718628-26-3
Molecular Formula	C9H11IZn
Molecular Weight	311.48 g/mol
Synonyms	Mesitylzinc Iodide; (2,4,6-Trimethylphenyl)zinc Iodide; Zinc, iodo(2,4,6-trimethylphenyl)-; (Mesityl)zinc Iodide; Trimethylphenylzinc Iodide; Iodo(mesityl)zinc; MesZnI
EINECS	Contact for details

Quality Control

Our 2,4,6-Trimethylphenylzinc Iodide is produced under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm identity, purity, and solution concentration (typically supplied in THF or ether). We provide comprehensive Certificates of Analysis (COA) detailing assay results by titration and impurity profiles. Our quality management system supports compliance with cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C or as specified on the label. This material is moisture-sensitive and easily oxidized; all handling and aliquoting must be performed under anhydrous, inert conditions using standard Schlenk or glovebox techniques.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (IR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (Zn basis)	≥ 95%
Solvent	Anhydrous Tetrahydrofuran or Diethyl Ether

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.