Description

(2S,3R,4S,5S,6R)-2-(4-Chloro-3-(4-Ethoxybenzyl)Phenyl)-6-(Hydroxymethyl)-2-Methoxytetrahydro-2H-Pyran-3,4,5-Triol is a high-purity, complex monosaccharide derivative with significant potential in advanced pharmaceutical research and development. This compound, identified by CAS 714269-57-5, is valued for its precise stereochemistry and functional groups, which make it a critical building block for synthesizing novel therapeutic agents. It is primarily sought by R&D teams and process chemists in the pharmaceutical, biotechnology, and fine chemical sectors for applications in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic and cardiovascular diseases.
• Glycoscience Research: Used as a precursor or standard in studies involving carbohydrate chemistry, enzyme inhibition, and glycobiology.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable synthesis of complex drug candidates.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies to explore new chemical entities for therapeutic applications.
• Bioconjugation: Potential use in the synthesis of antibody-drug conjugates (ADCs) or other targeted drug delivery systems due to its modifiable hydroxyl groups.

Basic Information

Product Name	(2S,3R,4S,5S,6R)-2-(4-Chloro-3-(4-Ethoxybenzyl)Phenyl)-6-(Hydroxymethyl)-2-Methoxytetrahydro-2H-Pyran-3,4,5-Triol
CAS No.	714269-57-5
Molecular Formula	C22H27ClO7
Molecular Weight	438.90 g/mol
Synonyms	Canagliflozin Impurity; Canagliflozin Related Compound; 1-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-1-deoxy-β-D-glucitol, 2-Methyl Ether; (2S,3R,4S,5S,6R)-2-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)-2-methoxyoxane-3,4,5-triol; β-D-Glucitol, 1-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-deoxy-, 2-methyl ether; Canagliflozin EP Impurity G; (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-2-O-methyl-D-glucitol
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and tested under a strict quality management system. We provide comprehensive analytical data to support your regulatory filings, including full characterization by NMR, MS, and HPLC. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot, ensuring compliance with ICH guidelines and internal specifications for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.