Description

4-(tert-Butyl-Dimethyl-Silanyloxy)-6-[2-(8-Hydroxy-2,6-Dimethyl-1,2,6,7,8,8A-Hexahydro Naphthalen-1-Yl)-Ethyl]-Tetrahydro-Pyran-2-One is a sophisticated, high-purity synthetic intermediate featuring a protected hydroxyl group and a complex polycyclic structure. This compound is of critical importance in advanced pharmaceutical research and development, particularly in the synthesis of complex, biologically active molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing key molecular frameworks.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates, particularly in steroid and terpenoid-related therapeutic areas.
• Advanced Organic Synthesis: Used in research laboratories for constructing intricate polycyclic and heterocyclic molecular architectures.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Medicinal Chemistry Research: Enables the exploration of structure-activity relationships (SAR) by providing a versatile, functionalized core scaffold.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) group allows for selective manipulation of other functional groups during complex syntheses.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	4-(tert-Butyl-Dimethyl-Silanyloxy)-6-[2-(8-Hydroxy-2,6-Dimethyl-1,2,6,7,8,8A-Hexahydro Naphthalen-1-Yl)-Ethyl]-Tetrahydro-Pyran-2-One
CAS No.	79902-31-1
Molecular Formula	C25H42O4Si
Molecular Weight	434.69 g/mol
Synonyms	4-[(tert-Butyldimethylsilyl)oxy]-6-[2-(8-hydroxy-2,6-dimethyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-1-yl)ethyl]tetrahydro-2H-pyran-2-one; 6-[2-(8-Hydroxy-2,6-dimethyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-1-yl)ethyl]-4-[(tert-butyldimethylsilyl)oxy]tetrahydro-2H-pyran-2-one; TBDMS-protected hexahydronaphthalenyl ethyl lactone intermediate; CAS 79902-31-1
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.