Description

m-Peg8-Tos CAS NO 79622-11-0 is a high-purity polyethylene glycol (PEG) derivative, specifically a monomethoxy PEG tosylate with an 8-unit ethylene oxide chain. This compound serves as a critical bifunctional linker and reagent in advanced organic synthesis and bioconjugation, enabling the controlled introduction of hydrophilic PEG chains to enhance solubility, stability, and pharmacokinetic properties. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery, protein modification, and polymer chemistry.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of antibody-drug conjugates (ADCs), prodrugs, and PEGylated therapeutics.
• Bioconjugation Reagent: Used to modify proteins, peptides, and oligonucleotides to improve their solubility, reduce immunogenicity, and prolong circulation half-life.
• Polymer Chemistry: Serves as a macro-initiator or functional monomer for creating amphiphilic block copolymers and functionalized hydrogels.
• Surface Modification: Employed to PEGylate nanoparticles, liposomes, and diagnostic agents to create stealth properties and enhance biocompatibility.
• Crosslinking Agent: Utilized in the preparation of crosslinked polymeric networks for controlled drug delivery systems.
• Chemical Biology Probes: A versatile tool for introducing PEG spacers into molecular probes and sensors.

Basic Information

Product Name	m-Peg8-Tos
CAS No.	79622-11-0
Molecular Formula	C24H42O11S
Molecular Weight	538.66 g/mol
Synonyms	Monomethoxy PEG8 Tosylate; mPEG8-OTs; 2-[2-[2-[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate; Poly(ethylene glycol) methyl ether tosylate (n=8); PEG8 Monomethyl Ether Tosylate; Tos-PEG8-OMe; 4-Methylbenzenesulfonic acid 2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl ester
EINECS	Contact for details

Quality Control

Our m-Peg8-Tos is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and cGMP manufacturing needs with documentation traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.