Description

N'-Nitrosonornicotine-n-Oxide is a nitrosamine derivative of nornicotine, a key compound in the study of tobacco-specific nitrosamines (TSNAs). This chemical is of significant importance for research and analytical purposes, particularly in toxicology and carcinogenicity studies related to tobacco products. It serves as a critical reference standard and analytical reagent for laboratories in the pharmaceutical, regulatory, and academic sectors focused on product safety and chemical risk assessment.

Application

• Analytical Reference Standard: Primary use as a high-purity certified standard for the quantification of tobacco-specific nitrosamines (TSNAs) in various matrices.
• Toxicological Research: Essential reagent in studies investigating the metabolism, genotoxicity, and carcinogenic mechanisms of nitrosamines.
• Pharmaceutical Impurity Profiling: Used in method development and validation for detecting and controlling nitrosamine impurities in active pharmaceutical ingredients (APIs) and drug products, in compliance with regulatory guidelines (e.g., FDA, EMA).
• Environmental and Food Safety Testing: Employed in analytical methods to assess TSNA contamination in environmental samples, food products, and agricultural commodities.
• Quality Control & Assurance: Serves as a critical component in the internal quality control protocols of testing laboratories to ensure accuracy and reliability of analytical results.

Basic Information

Product Name	N'-Nitrosonornicotine-n-Oxide
CAS No.	78246-24-9
Molecular Formula	C9H11N3O2
Molecular Weight	193.20 g/mol
Synonyms	4-(Methylnitrosamino)-1-(3-pyridinyl)-1-butanone N-Oxide; NNN N-Oxide; N'-Nitrosonornicotine 1'-N-Oxide; NNK N-Oxide (common mis-association); 1-(3-Pyridinyl)-4-(methylnitrosamino)-1-butanone N-Oxide; N-Nitrosonornicotine N-Oxide; TSNA Reference Standard
EINECS	Contact for details

Quality Control

Our N'-Nitrosonornicotine-n-Oxide is manufactured and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and identity verification by spectroscopic methods (IR, NMR), to ensure it meets the high standards required for research and analytical applications. Certificates of Analysis (COA) with detailed batch-specific data are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.