Description

Milbemycin D is a potent macrocyclic lactone belonging to the milbemycin family of natural products, a key intermediate in the synthesis of high-value veterinary and agricultural acaricides and anthelmintics. Its significance lies in its role as a crucial building block for developing next-generation, broad-spectrum parasiticides that offer enhanced efficacy and safety profiles. This compound is essential for manufacturers and R&D facilities in the animal health and crop protection sectors seeking to innovate and produce advanced end-use formulations.

Application

• Veterinary Pharmaceutical Intermediate: A critical precursor in the synthesis of milbemycin oxime and other milbemycin-based endectocides used for heartworm prevention and treatment of internal and external parasites in companion animals and livestock.
• Agrochemical Synthesis: Serves as a key starting material for manufacturing milbemycin analogs with potent acaricidal and insecticidal activity for crop protection products.
• Research & Development: Used in biochemical and pharmacological research to study the mode of action of macrocyclic lactones on invertebrate glutamate-gated chloride channels.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for the identification and quantification of milbemycin components in active pharmaceutical ingredients (APIs) and finished products.
• Process Chemistry: Utilized in the development and scale-up of fermentation and semi-synthetic production processes for milbemycin derivatives.

Basic Information

Product Name	Milbemycin D
CAS No.	77855-81-3
Molecular Formula	C₃₂H₄₆O₇
Molecular Weight	542.71 g/mol
Synonyms	Milbemycin D; LL-F28249α; 5-O-Demethylmilbemycin α; (2aE,4E,8E)-5-[(1S,2S,6R,7S,8S,9S)-9-Ethyl-2,6,8-trimethyl-1,3-dioxolo[4,5-h][2]benzoxepin-7-yl]-2a,5-dihydro-2-methyl-2H-cyclohepta[b]furan-4,8(3H,7H)-dione; LL-F28249 alpha; Milbemycin alpha 1
EINECS	Contact for details

Quality Control

Our Milbemycin D is produced and tested under a strict quality management system to ensure batch-to-batch consistency and high purity suitable for synthesis and research applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥95.0%
Related Substances (HPLC)	Total impurities ≤5.0%
Single Maximum Impurity	≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.