Description

6β-[(Trimethylsilyl)Oxy]-5α-Cholestane is a high-purity, organosilicon-modified steroidal derivative. This compound serves as a critical intermediate and reference standard in advanced organic synthesis and analytical research. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of fine chemicals for developing and calibrating analytical methods.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel steroidal drugs and active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used for method development, validation, and quality control in HPLC, GC-MS, and NMR analysis within pharmaceutical and research settings.
• Biochemical Research: Employed in studies of cholesterol metabolism, membrane biology, and as a probe for investigating sterol-protein interactions.
• Fine Chemical Synthesis: Serves as a protected sterol precursor for the preparation of more complex, functionalized steroid analogs.
• Material Science: Potential use in the development of liquid crystals and advanced organic materials due to its modified steroidal structure.

Basic Information

Product Name	6β-[(Trimethylsilyl)Oxy]-5α-Cholestane
CAS No.	77828-27-4
Molecular Formula	C₃₀H₅₄OSi
Molecular Weight	458.84 g/mol
Synonyms	5α-Cholestan-6β-ol, trimethylsilyl ether; 6β-(Trimethylsiloxy)-5α-cholestane; 5α-Cholestan-6β-yloxytrimethylsilane; Cholestane, 6β-[(trimethylsilyl)oxy]-5α-; 6β-Trimethylsilyloxy-5α-cholestane; TMS-Cholestane derivative
EINECS	Contact for details

Quality Control

Our 6β-[(Trimethylsilyl)Oxy]-5α-Cholestane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity assay, NMR and IR identification, and residual solvent analysis, to ensure it meets stringent specifications for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.