Description

Pent-4-Ynyl p-Tosylate is a specialized organic building block featuring a terminal alkyne group protected by a p-toluenesulfonate (tosylate) leaving group. This molecular architecture makes it a versatile intermediate for advanced organic synthesis, particularly in constructing complex molecules through cross-coupling and nucleophilic substitution reactions. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers in the development of active pharmaceutical ingredients (APIs) and novel materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Cross-Coupling Reactions: Serves as a substrate in Sonogashira, Suzuki, and other palladium-catalyzed coupling reactions to introduce alkyne functionalities.
• Nucleophilic Substitution: The tosylate group is an excellent leaving group, facilitating SN2 reactions with various nucleophiles.
• Material Science Research: Used in the development of polymers, dendrimers, and organic electronic materials with tailored properties.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents and herbicides.
• Academic & R&D: A valuable reagent for synthetic organic chemistry research in university and industrial laboratories.

Basic Information

Product Name	Pent-4-Ynyl p-Tosylate
CAS No.	77758-50-0
Molecular Formula	C₁₄H₁₈O₃S
Molecular Weight	266.36 g/mol
Synonyms	4-Pentyn-1-yl 4-methylbenzenesulfonate; 4-Pentynyl tosylate; p-Toluenesulfonic acid 4-pentynyl ester; 1-Tosyloxy-4-pentyne; 4-Pentyn-1-ol tosylate; Pent-4-yn-1-yl tosylate; 4-Pentynyl p-toluenesulfonate
EINECS	Contact for details

Quality Control

Our Pent-4-Ynyl p-Tosylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications in regulated environments, including cGMP for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in darkness.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.