Description

Tetraazatetramethyl-12-Crown-4 is a specialized macrocyclic polyamine ligand, a member of the crown ether family with nitrogen donor atoms. This compound is valued for its strong and selective binding affinity for transition metal ions and protons, making it a crucial component in advanced chemical synthesis and separation processes. It is primarily utilized by researchers and manufacturers in the fields of coordination chemistry, catalysis, and as a phase-transfer agent for demanding industrial and pharmaceutical applications.

Application

• Coordination Chemistry & Catalyst Ligand: Acts as a chelating agent for transition metals (e.g., Cu, Ni, Co) to form stable complexes used in homogeneous catalysis.
• Phase-Transfer Catalysis (PTC): Facilitates reactions between reagents in immiscible phases, enhancing reaction rates and yields in organic synthesis.
• Ion-Selective Electrodes & Sensors: Serves as an ionophore in membrane formulations for detecting specific metal cations.
• Metal Ion Extraction & Separation: Used in solvent extraction processes for the selective recovery and purification of valuable or toxic metal ions from solutions.
• Polymer Stabilization: Functions as a metal deactivator and stabilizer in polymer formulations to prevent catalytic degradation.
• Pharmaceutical Intermediate Synthesis: Employed in the synthesis of complex molecules where controlled metal coordination is required.
• Analytical Chemistry: Utilized as a masking agent or complexing agent in titrimetric and spectrophotometric analyses.
• Research & Development: A key reagent in academic and industrial R&D for developing new catalytic systems and materials.

Basic Information

Product Name	Tetraazatetramethyl-12-Crown-4
CAS No.	76282-33-2
Molecular Formula	C12H28N4O4
Molecular Weight	292.38 g/mol
Synonyms	1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid tetramethyl ester; 1,4,7,10-Tetrakis(methoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane; Me4DOTA tetramethyl ester; DOTA-tetramethyl ester; Tetramethyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate; 12-Crown-4, N,N',N'',N'''-tetramethyl derivative; Tetraazacyclododecane tetraacetic acid tetramethyl ester
EINECS	Contact for details

Quality Control

Our Tetraazatetrimethyl-12-Crown-4 is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance. Standard quality checks include assay (HPLC), identification (IR, NMR), and impurity profiling. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.