Description

1-(4'-Nitrophenyl)-2-Trimethylsilyl Acetylene is a specialized organosilicon building block featuring a nitrophenyl group and a protected acetylene moiety. This compound matters as a versatile intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures through cross-coupling and cycloaddition reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of potential drug candidates, particularly those containing arylacetylene or heterocyclic structures.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its functional groups for structural diversification.
• Material Science Precursor: Serves as a monomer or building block for advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: Employed in Sonogashira, Heck, and other palladium-catalyzed couplings to introduce the (4-nitrophenyl)acetylene unit into target molecules.
• Click Chemistry: The alkyne functionality makes it suitable for Huisgen 1,3-dipolar cycloaddition reactions, a cornerstone of bioconjugation and polymer chemistry.
• Organic Synthesis Research: A valuable reagent in academic and industrial laboratories for methodology development and the synthesis of complex natural product analogs.

Basic Information

Product Name	1-(4'-Nitrophenyl)-2-Trimethylsilyl Acetylene
CAS No.	75867-38-8
Molecular Formula	C11H13NO2Si
Molecular Weight	219.31 g/mol
Synonyms	4-Nitrophenyl(trimethylsilyl)acetylene; (4-Nitrophenyl)ethynyltrimethylsilane; Trimethyl((4-nitrophenyl)ethynyl)silane; 1-Trimethylsilyl-2-(4-nitrophenyl)acetylene; 4-(Trimethylsilylethynyl)nitrobenzene; p-Nitrophenyl trimethylsilyl acetylene; TMS-protected 4-ethynylnitrobenzene
EINECS	Contact for details

Quality Control

Our 1-(4'-Nitrophenyl)-2-Trimethylsilyl Acetylene is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality systems are designed to meet the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.