Description

6-Cyano-3,4-Dihydro-2,2-Dimethyl-trans-4-(1-Pyrrolidinyl)-2H-Benzo-[B]-Pyrano-3-Ol is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular research. It is primarily sought by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel therapeutic agents targeting neurological and cardiovascular pathways.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Process Chemistry Development: Serves as a critical raw material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Utilized as an analytical standard for quality control and method validation in API manufacturing.
• Academic & Institutional Research: Employed in synthetic organic chemistry projects and the development of new catalytic or asymmetric methodologies.

Basic Information

Product Name	6-Cyano-3,4-Dihydro-2,2-Dimethyl-trans-4-(1-Pyrrolidinyl)-2H-Benzo-[B]-Pyrano-3-Ol
CAS No.	75611-78-8
Molecular Formula	C₁₇H₂₀N₂O₂
Molecular Weight	284.36 g/mol
Synonyms	trans-4-(1-Pyrrolidinyl)-6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ol; 6-Cyano-3,4-dihydro-2,2-dimethyl-4-(1-pyrrolidinyl)-2H-1-benzopyran-3-ol; 2H-1-Benzopyran-3-ol, 6-cyano-3,4-dihydro-2,2-dimethyl-4-(1-pyrrolidinyl)-, trans-; (3R,4S)-6-Cyano-3,4-dihydro-2,2-dimethyl-4-(pyrrolidin-1-yl)-2H-chromen-3-ol (stereospecific); Chroman derivative 75611-78-8; Pyrrolidinyl chromanol nitrile.
EINECS	Contact for details

Quality Control

Our 6-Cyano-3,4-Dihydro-2,2-Dimethyl-trans-4-(1-Pyrrolidinyl)-2H-Benzo-[B]-Pyrano-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and comprehensive identification and impurity profiling. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee (trans-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.