Description

Apigenin-7-Diglucuronide CAS NO 74696-01-8 is a flavonoid glucuronide metabolite, specifically the 7-O-diglucuronide conjugate of the bioactive flavone apigenin. This compound is of significant interest for its role as a key biomarker and active metabolite in pharmacokinetic and pharmacodynamic studies. It is primarily utilized by research institutions, pharmaceutical developers, and nutraceutical companies engaged in advanced analytical research, bioavailability studies, and the development of standardized herbal extracts.

Application

• Biomarker in Clinical & Preclinical Research: Used as a reference standard in LC-MS/MS and HPLC assays to quantify apigenin exposure and metabolism in biological fluids.
• Pharmacokinetic Studies: Essential for investigating the absorption, distribution, metabolism, and excretion (ADME) profiles of apigenin and apigenin-rich products.
• Pharmaceutical Reference Standard: Serves as a high-purity certified material for method development, validation, and quality control in drug development pipelines.
• Nutraceutical & Herbal Extract Standardization: Employed to standardize and authenticate complex botanical extracts, such as chamomile or parsley, ensuring consistent bioactive metabolite profiles.
• Metabolite Synthesis & Isolation: Acts as a starting material or target compound for the synthesis of other flavonoid metabolites for biological testing.
• Academic Research: Used in studies exploring the anti-inflammatory, antioxidant, or other mechanistic activities of flavonoid conjugates.

Basic Information

Product Name	Apigenin-7-Diglucuronide
CAS No.	74696-01-8
Molecular Formula	C27H26O18
Molecular Weight	638.49 g/mol
Synonyms	Apigenin 7-O-β-D-diglucuronide; Apigenin-7-O-diglucuronide; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 7-(β-D-glucopyranuronosyl-(1→2)-β-D-glucopyranosiduronic acid); 4',5,7-Trihydroxyflavone-7-diglucuronide; Apigenin 7-diglucuronide
EINECS	Contact for details

Quality Control

Our Apigenin-7-Diglucuronide is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (UV, MS). A Certificate of Analysis (COA) detailing batch-specific results is provided to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. For long-term storage, consider keeping the material under inert atmosphere or at -20°C to ensure maximum stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.