Description

Tetrahydro-α,3,4,5-Tetrakis[(Trimethylsilyl)Oxy]-2-Furanacetaldehyde is a highly functionalized, protected carbohydrate derivative, specifically a silylated tetrahydrofurfural. This compound is a critical synthetic intermediate valued for its role in constructing complex molecular architectures. It is primarily utilized by pharmaceutical and fine chemical research organizations engaged in the development of novel active ingredients and chiral building blocks.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of nucleoside analogs, antiviral agents, and other complex bioactive molecules.
• Glycochemistry Research: Serves as a protected sugar aldehyde precursor for the preparation of C-glycosides, glycomimetics, and complex oligosaccharides.
• Asymmetric Synthesis: Used as a starting material or building block in stereoselective reactions to introduce functionalized tetrahydrofuran rings.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Material Science: Potential monomer or precursor for synthesizing novel polymers with specific functional properties.

Basic Information

Product Name	Tetrahydro-α,3,4,5-Tetrakis[(Trimethylsilyl)Oxy]-2-Furanacetaldehyde
CAS No.	74685-70-4
Molecular Formula	C18H40O6Si4
Molecular Weight	464.86 g/mol
Synonyms	2-Furanacetaldehyde, tetrahydro-α,3,4,5-tetrakis[(trimethylsilyl)oxy]-; Tetrahydro-2-furanacetaldehyde, α,3,4,5-tetrakis-O-(trimethylsilyl)-; Per-O-trimethylsilylated tetrahydrofurfural; (Tetrahydro-2-furyl)glyoxal per-TMS ether; 2-[(Trimethylsilyl)oxy]methyl]-5-[(trimethylsilyl)oxy]tetrahydrofuran-3,4-diyl bis(trimethylsilyl) ether; Protected tetrahydrofurfural; TMS-protected THF aldehyde.
EINECS	Contact for details

Quality Control

Our high-purity Tetrahydro-α,3,4,5-Tetrakis[(Trimethylsilyl)Oxy]-2-Furanacetaldehyde is manufactured under strict quality management protocols. Each batch is characterized and tested to ensure identity, purity, and consistency, meeting the exacting standards required for research and process development. Certificates of Analysis (COA) detailing comprehensive analytical results (including HPLC, NMR, and GC data) are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and easily oxidized nature. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.