Description

tert-Butyl-4-Chloro-3-Oxobutanoate is a high-purity organic building block and pharmaceutical intermediate of significant commercial importance. Its reactive β-keto ester and chloro functionalities make it a versatile precursor for synthesizing complex molecules, particularly in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of various active pharmaceutical ingredients (APIs), including potential candidates for cardiovascular, anti-inflammatory, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators, leveraging its reactive sites for structural diversification.
• Fine Chemical Production: Serves as a crucial starting material for manufacturing complex dyes, pigments, and specialty polymers requiring specific chlorinated keto-ester backbones.
• Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic pathways, heterocyclic chemistry, and method development.
• Peptide Mimetics & Prodrug Synthesis: Utilized in the design and synthesis of peptide analogs and prodrug formulations, where the tert-butyl ester group offers advantageous stability and pharmacokinetic properties.

Basic Information

Product Name	tert-Butyl-4-Chloro-3-Oxobutanoate
CAS No.	74530-56-6
Molecular Formula	C8H13ClO3
Molecular Weight	192.64 g/mol
Synonyms	4-Chloro-3-oxobutanoic acid tert-butyl ester; tert-Butyl 4-chloroacetoacetate; 4-Chloroacetoacetic acid tert-butyl ester; 3-Oxobutanoic acid, 4-chloro-, 1,1-dimethylethyl ester; Butanoic acid, 4-chloro-3-oxo-, 1,1-dimethylethyl ester; Acetoacetic acid, 4-chloro-, tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl-4-Chloro-3-Oxobutanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment, supporting compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider holding under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.