Description

D -(-)-S-Acetyl-β-Mercapto- Isobutyric Acid CAS NO 74431-52-0 is a high-purity chiral intermediate featuring a protected thiol group. This compound is critical for the synthesis of enantiomerically pure pharmaceuticals and fine chemicals, ensuring the precise stereochemistry required for biological activity. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors for developing active pharmaceutical ingredients (APIs) and specialty compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of chiral drugs, particularly ACE inhibitors and other cardiovascular or neurological therapeutics.
• Peptide Synthesis: Used as a protected cysteine analog or a thiol-containing moiety in the production of custom peptides and peptidomimetics.
• Agrochemical Research: Serves as a precursor for chiral active ingredients in herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands for asymmetric catalysis and metal complexation.
• Bioconjugation Chemistry: Utilized for introducing thiol-reactive handles onto biomolecules or polymers for drug delivery systems.
• Fine Chemical Synthesis: A versatile chiral synthon for constructing complex organic molecules in academic and industrial research.

Basic Information

Product Name	D -(-)-S-Acetyl-β-Mercapto- Isobutyric Acid
CAS No.	74431-52-0
Molecular Formula	C6H10O3S
Molecular Weight	162.21 g/mol
Synonyms	(R)-3-(Acetylthio)-2-methylpropanoic Acid; D-3-(Acetylthio)-2-methylpropionic Acid; (R)-3-Acetylthio-2-methylpropionic Acid; (R)-S-Acetyl-3-mercapto-2-methylpropionic Acid; D-(-)-S-Acetyl-β-mercaptoisobutyric Acid; (R)-ATMI; D-ATMI; (2R)-3-(Acetylsulfanyl)-2-methylpropanoic Acid
EINECS	Contact for details

Quality Control

Our D -(-)-S-Acetyl-β-Mercapto- Isobutyric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee consistent quality, identity, and purity for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.