Description

1-Deoxy-1-(Bis(2-Chloroethyl)Amino)-2,3,4-o-Tetraacetyl-β-D-Ribopyr Anose is a key nitrogen mustard sugar derivative, serving as a critical advanced intermediate in the synthesis of complex bioactive molecules. Its value lies in providing a protected sugar scaffold with a reactive alkylating moiety, enabling precise chemical modifications for targeted drug development. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on developing novel chemotherapeutic agents and nucleotide analogs.

Application

• Pharmaceutical Intermediate: A vital building block for the synthesis of nitrogen mustard-linked nucleoside analogs and prodrugs with potential anticancer activity.
• Anticancer Agent Research: Used in medicinal chemistry research to develop new alkylating agents that target DNA for oncology applications.
• Bioconjugation Chemistry: Serves as a specialized reagent for attaching cytotoxic payloads to sugars, peptides, or antibodies in targeted therapy development.
• Nucleotide Chemistry: Employed in the modification of ribose sugars to create novel nucleotide derivatives for biochemical studies.
• Chemical Biology Probes: Utilized in the creation of molecular probes to study enzyme mechanisms and cellular pathways involving alkylation.
• Process Development: Acts as a key intermediate in the scale-up and process optimization for active pharmaceutical ingredient (API) manufacturing.

Basic Information

Product Name	1-Deoxy-1-(Bis(2-Chloroethyl)Amino)-2,3,4-o-Tetraacetyl-β-D-Ribopyr Anose
CAS No.	74427-66-0
Molecular Formula	C₁₇H₂₅Cl₂NO₈
Molecular Weight	442.29 g/mol
Synonyms	1-Deoxy-1-[bis(2-chloroethyl)amino]-2,3,4-tri-O-acetyl-β-D-ribopyranose; 1-Deoxy-1-(bis(2-chloroethyl)amino)-2,3,4-tri-O-acetyl-β-D-ribopyranose; β-D-Ribopyranose, 1-deoxy-1-[bis(2-chloroethyl)amino]-, 2,3,4-triacetate; Nitrogen Mustard Ribose Tetraacetate; 1-(Bis(2-chloroethyl)amino)-1-deoxy-2,3,4-tri-O-acetyl-β-D-ribopyranose; NSC 176319
EINECS	Contact for details

Quality Control

Our 1-Deoxy-1-(Bis(2-Chloroethyl)Amino)-2,3,4-o-Tetraacetyl-β-D-Ribopyr Anose is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.