Description

2-Oxopentanoic Acid Trimethylsilyl Ester is a specialized organosilicon derivative of levulinic acid, serving as a key protected intermediate in advanced organic synthesis. This compound is valued for its role in introducing the trimethylsilyl (TMS) protecting group, which enhances the stability and solubility of reactive carbonyl functionalities under demanding reaction conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and novel materials.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing complex drug molecules and active pharmaceutical ingredients (APIs), particularly where carbonyl protection is required.
• Agrochemical Synthesis: Used in the research and development of novel pesticides, herbicides, and plant growth regulators.
• Fine Chemical Production: Serves as a protected synthon in multi-step organic synthesis for high-value specialty chemicals.
• Academic & Industrial Research: A valuable reagent in method development and exploratory chemistry for creating new carbon-carbon bonds.
• Material Science: Potential precursor in the development of silicon-containing polymers or hybrid organic-inorganic materials.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes due to its handling characteristics as a volatile, protected species.

Basic Information

Product Name	2-Oxopentanoic Acid Trimethylsilyl Ester
CAS No.	74367-69-4
Molecular Formula	C8H16O3Si
Molecular Weight	188.30 g/mol
Synonyms	4-Oxopentanoic Acid Trimethylsilyl Ester; Levulinic Acid Trimethylsilyl Ester; 4-Oxovaleric Acid TMS Ester; Trimethylsilyl Levulinate; TMS Levulinate; 4-Ketovaleric Acid Trimethylsilyl Ester; (Trimethylsilyl) 4-oxopentanoate
EINECS	Contact for details

Quality Control

Our 2-Oxopentanoic Acid Trimethylsilyl Ester is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure batch-to-batch consistency and high purity. Quality is verified using advanced techniques including Gas Chromatography (GC) and Nuclear Magnetic Resonance (NMR) spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature, store in a cool, well-ventilated place at a recommended temperature of 2-8°C (refrigerated). Keep the container tightly sealed when not in use to prevent evaporation and potential moisture ingress. Store away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.