Description

n-[[(Diethoxyphosphinyl)Thio]Acetyl]-L-Valine is a specialized organophosphorus compound that serves as a key chiral intermediate in advanced chemical synthesis. Its molecular architecture, featuring a valine-derived chiral center and a protected phosphorothioate group, makes it a critical building block for creating enantiomerically pure products. This high-purity intermediate is essential for research and production in the pharmaceutical and agrochemical sectors, where precise stereochemistry is paramount for biological activity and regulatory approval.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the development of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in protease inhibitor research.
• Agrochemical Synthesis: Used in the production of advanced, chiral pesticides and herbicides where specific stereoisomers exhibit enhanced efficacy and environmental safety.
• Peptidomimetic Research: Serves as a backbone-modified amino acid analog for constructing novel peptide-like molecules in drug discovery programs.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes for studying enzyme mechanisms, particularly those involving serine hydrolases.
• Ligand and Catalyst Development: Acts as a precursor for chiral phosphine- or phosphonate-containing ligands used in asymmetric catalysis.

Basic Information

Product Name	n-[[(Diethoxyphosphinyl)Thio]Acetyl]-L-Valine
CAS No.	74107-58-7
Molecular Formula	C11H22NO6PS
Molecular Weight	327.33 g/mol
Synonyms	L-Valine, N-[[(diethoxyphosphinyl)thio]acetyl]-; N-[(Diethoxyphosphinothioyl)thioacetyl]-L-valine; Acetyl-L-valine diethyl phosphorothioate; (S)-2-((((Diethoxyphosphoryl)thio)acetyl)amino)-3-methylbutanoic acid; Valine phosphorothioate derivative; Chiral valine phosphonate ester; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our n-[[(Diethoxyphosphinyl)Thio]Acetyl]-L-Valine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the exacting standards required for pharmaceutical and advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can compromise product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.