Description

8-(4-Methylphenyl)Sulfonyloxy-1-Azabicyclo[2.2.2]Octane is a specialized bicyclic tertiary amine derivative, valued as a key synthetic intermediate and building block in advanced organic chemistry. Its unique bridged structure and sulfonyloxy functional group make it a versatile precursor for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for chemists and R&D teams in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new active ingredients or novel materials.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting the central nervous system (CNS) due to its quinuclidine-like scaffold.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where its structural features can contribute to biological activity.
• Ligand and Catalyst Development: Acts as a starting material for creating sophisticated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing high-value, low-volume specialty chemicals.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic synthesis, including novel coupling reactions and heterocycle formation.

Basic Information

Product Name	8-(4-Methylphenyl)Sulfonyloxy-1-Azabicyclo[2.2.2]Octane
CAS No.	73855-50-2
Molecular Formula	C14H19NO3S
Molecular Weight	281.37 g/mol
Synonyms	8-(p-Toluenesulfonyloxy)quinuclidine; 1-Azabicyclo[2.2.2]octan-8-yl 4-methylbenzenesulfonate; Quinuclidin-8-yl tosylate; 8-Tosyloxyquinuclidine; 8-Quinuclidinol tosylate; Tosylquinuclidinol; 8-Hydroxyquinuclidine tosylate
EINECS	Contact for details

Quality Control

Our 8-(4-Methylphenyl)Sulfonyloxy-1-Azabicyclo[2.2.2]Octane is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Consider storing under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.