Description

Methanesulfonic Acid, Trifluoro-, 2-Chloroethyl Ester is a specialized organofluorine building block and a reactive intermediate of significant interest in advanced chemical synthesis. This compound matters for its ability to introduce both trifluoromethanesulfonate (triflate) and chloroethyl functional groups, enabling precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring triflate ester chemistry for cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the chloroethyl group provides a handle for further derivatization.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the surface modification of polymers and the synthesis of functional monomers for specialty materials.
• Fluorination Reagent: Acts as a source of the trifluoromethanesulfonyl group in nucleophilic substitution reactions to introduce fluorine-containing motifs.
• Cross-Coupling Reactions: An effective electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form carbon-carbon bonds.

Basic Information

Product Name	Methanesulfonic Acid, Trifluoro-, 2-Chloroethyl Ester
CAS No.	73323-80-5
Molecular Formula	C3H4ClF3O3S
Molecular Weight	212.57 g/mol
Synonyms	2-Chloroethyl Trifluoromethanesulfonate; Trifluoromethanesulfonic Acid 2-Chloroethyl Ester; 2-Chloroethyl Triflate; 2-Chloroethyl Trifluoromethanesulphonate; 1-Chloro-2-[(trifluoromethyl)sulfonyl]oxyethane; Ethanol, 2-chloro-, 1-trifluoromethanesulfonate; CF3SO2OCH2CH2Cl
EINECS	Contact for details

Quality Control

Our Methanesulfonic Acid, Trifluoro-, 2-Chloroethyl Ester is produced under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.