Description

(S)-4-[(2,6-Dimethylphenyl)Methyl]-3,4,5,6-Tetrahydro-3-Methylene-2H-Pyran-2-One is a high-purity chiral lactone building block of significant interest in advanced organic synthesis. Its value lies in its stereochemically defined structure, which is critical for developing enantiomerically pure compounds with targeted biological activity. This product is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the production of advanced, stereoselective pesticides and herbicides where specific chirality enhances efficacy and reduces environmental impact.
• Asymmetric Catalysis Research: Serves as a valuable substrate or ligand precursor in the development and testing of new chiral catalysts and synthetic methodologies.
• Fine Chemical Production: Employed in the multistep synthesis of complex fragrance molecules, flavors, and other specialty chemicals requiring high stereochemical purity.
• Academic & Institutional Research: A critical compound for studies in organic chemistry, medicinal chemistry, and total synthesis projects within university and corporate R&D laboratories.

Basic Information

Product Name	(S)-4-[(2,6-Dimethylphenyl)Methyl]-3,4,5,6-Tetrahydro-3-Methylene-2H-Pyran-2-One
CAS No.	72776-46-6
Molecular Formula	C15H18O2
Molecular Weight	230.30 g/mol
Synonyms	(S)-4-(2,6-Dimethylbenzyl)-3-methylenedihydro-2H-pyran-2-one; (3S)-4-[(2,6-Dimethylphenyl)methyl]-3-methylidene-3,4,5,6-tetrahydro-2H-pyran-2-one; (S)-3-Methylene-4-(2,6-xylylmethyl)dihydro-2H-pyran-2-one; Lactone building block 72776-46-6; Chiral dihydropyranone derivative
EINECS	Contact for details

Quality Control

Every batch of (S)-4-[(2,6-Dimethylphenyl)Methyl]-3,4,5,6-Tetrahydro-3-Methylene-2H-Pyran-2-One is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and chiral purity are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.