Description

1,5-Anhydro-2-Deoxy-4,6-o-(Phenylmethylene)-3-o-[(Tributylstannyl)Methyl]-D-Ribo-Hex-1-Enitol is a sophisticated organotin-functionalized carbohydrate derivative, serving as a critical synthetic intermediate in advanced organic and medicinal chemistry. Its unique structure, combining a protected sugar scaffold with a reactive tributylstannyl moiety, makes it invaluable for palladium-catalyzed cross-coupling reactions like the Stille reaction. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for constructing complex nucleoside analogs and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Stille Reaction Precursor: Serves as a versatile organotin reagent for cross-coupling with aryl, vinyl, or acyl halides to form new carbon-carbon bonds in complex molecule assembly.
• Glycochemistry Research: Used in the study and synthesis of modified sugars and glycomimetics for drug discovery and biochemical probes.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and the development of targeted therapeutic agents.
• Process Chemistry Development: Utilized in route scouting and scale-up processes for the production of active pharmaceutical ingredients (APIs).
• Bioconjugation: Potential use in creating labeled carbohydrate derivatives for diagnostic or imaging applications.

Basic Information

Product Name	1,5-Anhydro-2-Deoxy-4,6-o-(Phenylmethylene)-3-o-[(Tributylstannyl)Methyl]-D-Ribo-Hex-1-Enitol
CAS No.	72246-03-8
Molecular Formula	C29H48O4Sn
Molecular Weight	579.39 g/mol
Synonyms	1,5-Anhydro-2-deoxy-4,6-O-(phenylmethylene)-3-O-[(tributylstannyl)methyl]-D-ribo-hex-1-enitol; 3-O-[(Tributylstannyl)methyl]-1,5-anhydro-2-deoxy-4,6-O-(phenylmethylene)-D-ribo-hex-1-enitol; Tributyl[((4,6-O-benzylidene-1,5-anhydro-2-deoxy-D-ribo-hex-1-enit-3-yl)oxy)methyl]stannane; D-Ribo-Hex-1-enitol, 1,5-anhydro-2-deoxy-4,6-O-(phenylmethylene)-3-O-[(tributylstannyl)methyl]-; Benzylidene-protected tributylstannylmethyl glycoside
EINECS	Contact for details

Quality Control

Our production of this advanced synthetic intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and reliability for critical research and development. Identity and purity are confirmed through a suite of analytical techniques including NMR (¹H, ¹³C, ¹¹⁹Sn), HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing assay, purity, and residual solvent levels is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consideration should be given to storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.