Description

(Chloromethyl)-Oxiran Reaction Products With Polyethylene Glycol is a specialized class of functionalized polymers derived from the reaction of epichlorohydrin with polyethylene glycol. This chemistry is critical for introducing reactive chloromethyl and oxirane (epoxide) groups onto a hydrophilic PEG backbone, creating versatile intermediates for further synthesis. These products are essential for manufacturers in the pharmaceutical, bioconjugation, and specialty polymer industries seeking to modify surfaces, create cross-linked hydrogels, or synthesize targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: Used in the synthesis of prodrugs, PEGylated active pharmaceutical ingredients (APIs), and targeted therapeutic conjugates.
• Bioconjugation Reagent: Serves as a heterobifunctional crosslinker for attaching molecules (e.g., drugs, dyes, proteins) to polymers, nanoparticles, or solid surfaces.
• Polymer Modification: Acts as a key monomer or crosslinking agent for producing functionalized hydrogels, coatings, and resins with tailored hydrophilicity and reactivity.
• Surface Functionalization: Employed to introduce reactive epoxide or chloromethyl groups onto material surfaces for subsequent immobilization of biomolecules or catalysts.
• Chromatography Media: Utilized in the manufacture of affinity chromatography supports and stationary phases for bioseparations.
• Adhesive & Sealant Formulations: Incorporated as a reactive modifier to enhance the properties of epoxy-based adhesives and sealants.

Basic Information

Product Name	(Chloromethyl)-Oxiran Reaction Products With Polyethylene Glycol
CAS No.	72207-80-8
Molecular Formula	Variable (Polymer)
Molecular Weight	Variable (Depends on PEG chain length and degree of substitution)
Synonyms	Epichlorohydrin-PEG Reaction Products; PEG Epichlorohydrin Copolymer; Poly(ethylene glycol) diglycidyl ether (related); Oxirane, (chloromethyl)-, polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl); Glycidyl Chloride-PEG Adduct; Polyethylene Glycol Chloromethyl Oxirane Polymer; Reactive PEG Derivative; PEG-based Epoxy Resin Intermediate
EINECS	Contact for details

Quality Control

Our (Chloromethyl)-Oxiran Reaction Products With Polyethylene Glycol are manufactured under a strict quality management system. Each batch undergoes comprehensive analysis to ensure consistency in key parameters such as epoxy value, chlorine content, molecular weight distribution, and functional group density. Certificates of Analysis (COA) detailing these specifications are provided with every shipment. We can support development and production needs across research, pilot, and commercial scales.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent hydrolysis and maintain reactivity. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Epoxy Value (Eq/kg)	Contact for details
Chlorine Content	Contact for details
Average Molecular Weight (GPC)	As per grade (e.g., PEG 400, 1000, 2000 based)
Water Content (KF)	< 0.5%
Viscosity	Reported per grade

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.