Description

6-Chloro-9,n-Bis(trimethylsilyl)-9H-purin-2-amine is a key silyl-protected purine derivative, a crucial building block in advanced organic synthesis. Its primary value lies in its role as a versatile intermediate for the development of nucleoside analogs, pharmaceuticals, and agrochemicals. This compound is essential for research and production facilities in the pharmaceutical, biotechnology, and fine chemical sectors, where precise molecular construction is required.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Agrochemical Research: Used in developing new classes of plant growth regulators and pesticides.
• Nucleic Acid Chemistry: Serves as a protected monomer for oligonucleotide synthesis and modification.
• Bioconjugation: Facilitates the labeling and modification of biomolecules for diagnostic applications.
• Academic & R&D: A valuable reagent for medicinal chemistry research and exploring new synthetic pathways.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex, high-value specialty chemicals.

Basic Information

Product Name	6-Chloro-9,n-Bis(trimethylsilyl)-9H-purin-2-amine
CAS No.	72101-44-1
Molecular Formula	C11H20ClN5Si2
Molecular Weight	313.94 g/mol
Synonyms	2-Amino-6-chloro-9H-purine-9,9-bis(trimethylsilyl); 6-Chloro-9H-purin-2-amine, 9,9-bis(trimethylsilyl)-; 6-Chloro-9-(trimethylsilyl)-9H-purin-2-amine, N-(trimethylsilyl)-; 2-Amino-6-chloropurine, 9,9-bis(trimethylsilyl) derivative; 72101-44-1; Purine, 2-amino-6-chloro-9,9-bis(trimethylsilyl)-; 9,n-Bis(trimethylsilyl)-6-chloro-9H-purin-2-amine
EINECS	Contact for details

Quality Control

Our 6-Chloro-9,n-Bis(trimethylsilyl)-9H-purin-2-amine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to support cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.